ESC: Increased sedentary time in childhood leads to higher left ventricular mass in young adulthood

30th August 2023

Being more sedentary in childhood leads to a higher left ventricular mass in young adulthood, which is an independent risk factor for cardiovascular events. This was the key finding of a study presented at the recent European Society of Cardiology (ESC) Congress 2023 in Amsterdam.

The study also revealed that this increased risk occurred even in those with a normal weight and blood pressure.

The first study to investigate the cumulative effect of smartwatch-assessed sedentary time in young people and cardiac damage later in life, the researchers asked children aged 11 to wear a smartwatch with an activity tracker for seven days. This was repeated at 15 years of age and again at age 24.

Echocardiography which the imaging modality of choice to assess left ventricular end-diastolic and end-systolic volumes, was used assess the mass of the left ventricle. Measurements were undertaken at ages 17 and 24 years of age and reported in grams relative to height (g/m^2.7).

Sedentary behaviour and left ventricular mass

The study enrolled 766 children (55% girls). At 11 years of age, the participants were sedentary for an average of 362 minutes a day. This rose to an average of 474 minutes a day in those 15 years of age, and further still to 531 minutes by age 24.

Sedentary time therefore increased by an average of 169 minutes or 2.8 hours per day between childhood and young adulthood.

The researchers calculated that each one-minute increase in sedentary time from 11 to 24 years of age, was associated with a 0.004 g/m^2.7 increase in left ventricular mass between the ages of 17 and 24 years.

When multiplied by 169 minutes of additional inactivity, this equates to a 0.7 g/m^2.7 daily rise – the equivalent of a 3 g increase in left ventricular mass between echocardiography measurements at the average height gain.

Study author Dr Andrew Agbaje of the University of Eastern Finland in Kuopio, Finland, said: ‘Children were sedentary for more than six hours a day and this increased by nearly three hours a day by the time they reached young adulthood.

‘Our study indicates that the accumulation of inactive time is related to heart damage regardless of body weight and blood pressure. Parents should encourage children and teenagers to move more by taking them out for a walk and limiting time spent on social media and video games’.

Should screening for undiagnosed hypertension in young adults be instigated?

9th May 2023

Undiagnosed hypertension appears to be present in a large number of young men and who seem to be otherwise healthy. Rod Tucker explores the evidence and discusses how screening young adults for the condition could have a big impact on patient care.

Globally, hypertension is the main cause of cardiovascular disease and leading cause of early death. Moreover, there are several recognised risk factors for the disease and modification of these can reduce the risk of developing hypertension. But to what extent does the condition remain undiagnosed and what specific factors contribute to this under-diagnosis?

This was a question posed in a recent report by the UK’s Office for National statistics (ONS). The team used data from a sample of 21,476 adults and examined both the prevalence of the condition and the degree to which it was undiagnosed. The report estimated that hypertension (defined as blood pressure greater than 140/90mmHg) affected approximately 32% of adults living in private households in England. An additional finding was the condition remained undetected in 29% of cases, which equates to some 4.2 million adults across England.

But perhaps of greater concern, was that hypertension was less likely to be diagnosed among younger adults, largely because, as a group, such individuals are generally perceived as having better health. The ONS analysis suggested that undiagnosed hypertension was present in 66% of men and 26% of women, aged 16-24.

To put this into perspective, the ONS estimated that only 17% of men and 21% of women aged 75 years and over – where hypertension is much more common – had undiagnosed disease. Although younger men were were proportionately more likely to be undiagnosed than older adults, the highest total estimated number of cases of unrecognised hypertension was seen in males aged 55-64 years (500,000 cases) and females aged 65-74 years (460,000 cases).

Risk factors for undiagnosed hypertension

But were there any specific factors or reasons to account for undiagnosed disease? In a further analysis, the ONS identified, for instance, hypertension was more prevalent when an individual self-reported their general health as ‘very good or good’ (males 41%, females 28%) compared with ‘bad or very bad’ (males 18%, females 14%). Interestingly, while being overweight or obese are recognised risk factors for the condition, undetected disease was actually more likely in men who were not overweight or obese (44%) compared with obese individuals (30%). Additional factors included those who had never smoked (36%) and if they lived in a rural (42%) as opposed to an urban location (32%).

What are the implications of these findings?

The authors of the report propose that their data provides valuable insight for health services to help improve outcomes. Yet, this immediately raises a problem for healthcare providers in that the current risk stratification process for hypertension screening is predicated on the fact that the disease has a lower prevalence in younger adults. For example, one US study of 21,581 individuals found that a normal blood pressure was observed in 57.8% of those aged 18-44.

In other work by the CDC in the US, hypertension was identified in just over a fifth (22.4%) of those aged 18-39. Consequently, younger adults are likely to be excluded from hypertension services. In fact, the recently introduced NHS community pharmacy blood pressure check service in the UK is designed to ‘identify people over the age of 40 who have previously not been diagnosed with hypertension’.

Is it right to exclude younger people from hypertension screening? While levels of hypertension are generally lower in the younger age group, this is confounded to some extent by the current obesity epidemic. For instance, it has been suggested that approximately 30% of obese adolescents have hypertension. Furthermore, other estimates are that one in eight adults aged between 20 and 40 years have hypertension and that it is associated with abnormalities on heart and brain imaging, increasing the likelihood of cardiovascular events by middle age. Nevertheless, despite these risks, there is currently a paucity of randomised trial data demonstrating a health benefit from blood pressure lowering in this patient group.

But if there is one important take-home message from the ONS report, it is that the current risk stratification for hypertension screening requires modification and should not be age-restricted. Screening young people, especially if they are either overweight or obese, would enable an assessment of end-organ damage in those with even mildly elevated blood pressure. This revised strategy would allow clinicians to provide relevant lifestyle advice and to instigate therapy where this fails. Such an approach would inevitably help to identify and improve outcomes for those with undiagnosed hypertension.

Cancer diagnoses in young people fell but ICU admissions increased during first wave of pandemic

19th November 2021

Cancer diagnoses in young people fell during the first-wave of the pandemic but were associated with a higher rate of ICU admissions

The level of cancer diagnoses in young people fell during the first-wave of the COVID-19 pandemic but there was also an increased likelihood of admission to intensive for cancers diagnosed during the period. This was the finding from a study by researchers from Oxford University, UK who discussed their findings in a poster presentation at the National Cancer Research Institute conference.

The COVID-19 pandemic has had a major impact on cancer services in the majority of countries across the world. In the UK, a survey by Cancer Research UK in July 2020, found that 2 in 3 cancer patients reported that their cancer care had been impacted and that ratings of overall cancer care as ‘very good’ decreased from 75% ‘before lockdown started’ to 37% ‘after lockdown started’. Moreover, other research shows that in England, there were approximately 3.4 million fewer key diagnostic tests performed between March and August 2020 compared with the same period in 2019.

Given the likely impact of delays in diagnostics, the Oxford team were interested in determining how in England, the first wave of the pandemic affected childhood, teenager and young adult cancer incidence rates, diagnostic and treatment time-intervals and cancer-related intensive care (ICU) admissions. They used the QResearch database, which is derived from the anonymised health records of over 35 million patients. In addition, since QReseaerch is also linked to linked to hospital admission, mortality and cancer diagnoses data held with a disease register, it was possible for the researchers to make links between these three factors. For the present study, researchers focused on central nervous system (CNS) tumours, lymphomas, leukaemias, sarcomas and renal tumours in those aged up to 25 years of age. They compared the incidence of these cancer diagnoses between 1^st February to the 15^th August 2020 and compared their findings to the three preceding pre-pandemic years. As well as the number of diagnoses, the team also analysed the length of time before treatment started after diagnosis and whether or not these patients were diagnosed after being admitted to intensive care.

Findings

A total of 2607 cancer diagnoses were made from 1^st January 2017-15^th August 2020, with 380 during the pandemic. Overall, this represented a 17% reduction (95% CI -38% to – 6%) in the incidence-rate-ratio during the first wave of the pandemic. In particular there was a 38% (95% CI -52% to -21%)] decrease in CNS tumours and a 28% (95% CI -45% to -5%) reduction in lymphomas. Interestingly, the researchers observed that childhood cancers that were diagnosed during the pandemic were more than twice as likely to be associated with an ICU admissions (adjusted odd ratio, OR = 2.2, 95% CI 1.33 – 3.47).

The researchers also observed that the median time to diagnosis was not significantly different across the different time periods (+4.5 days, 95% CI -20.5 days to +29.5) and the median time to treatment was actually shorter during the pandemic (-0.7 days, 95% CI -1.1 to -0.30).

The authors concluded that the COVID-19 pandemic led to substantial reduction in the detection of cancer in young adults but was also associated with an increase in cancer-related ICU admissions. They suggested that this was probably due to more severe baseline disease at diagnosis and that overall, their findings demonstrate a clear disruption to cancer diagnostic pathways in this age group which need to be addressed urgently in the recovery phase of the pandemic.

Citation

Saatci D et al. The impact of the COVID-19 pandemic on cancer diagnostic pathways in children, teenagers and young adults: a cohort study in England. NCRI conference 2021