Scientists at the University of Birmingham in the UK have found a potential new target to treat inflammatory disease.
This study focussed on the role of lactate in how the body’s immune system responds to inflammation.
Dr Valentina Pucino, of the University of Birmingham, said: “The recent discovery of the fundamental role of metabolism in immune cell biology is contributing immensely to our understanding of immune cell regulation.”
Dr Michelangelo Certo, of the University of Birmingham, added: “So far, most studies have focused on the role of metabolic pathways in the establishment of the immune response.
“Lactate has mainly been seen as a by-product of metabolism or as a biomarker in critical care at best, rather than a bioactive molecule, and its functional effects have thus been neglected for a long time.
“However, far from being inert, the accumulation of lactate in the cells, molecules and structures of tissue is found in both inflammatory disease and cancer.”
In this study, the researchers analysed the response of immune cells to lactate in chronic inflammation caused by rheumatoid arthritis.
In their research, which involved the use of mice, they also used blood from healthy patients and patients with arthritis, as well as joint biopsies, and tonsils removed following tonsillectomies due to the fact that inflamed tonsils share similarities with an inflamed joint.
Dr Claudio Mauro, of the University of Birmingham’s Institute of Inflammation and Ageing, said: “We identified the pathway initiated by lactate build-up in inflamed tissue that exacerbates the inflammatory response.
“We also now can provide evidence that molecules made by immune cells to transport sodium lactate – the sodium salt of lactic acid – could be a target for treatment to stop this lactate build-up in chronic inflammatory disorders.”
