Dapagliflozin is a sodium-glucose co-transporter 2 inhibitor which has received EU approval for use in symptomatic chronic heart failure
The anti-diabetic drug, dapagliflozin (brand name Forxiga) has been approved in the EU for patients with heart failure across the full spectrum of ejection fractions its manufacturer AstraZeneca has announced.
It has been estimated that globally, 64.3 million people are living with heart failure and chronic heart failure represents a leading cause of hospitalisation among those 65 years and older. Although dapagliflozin, which is a sodium-glucose cotransporter-2 inhibitor, used in the management of type 2 diabetes, it also appears to reduce adverse outcomes in patients with heart failure. In fact, studies have shown how the drug is effective in type 2 diabetics and heart failure, with an ejection fraction of less than 40%. Furthermore, in pursuing the value of the drug in heart failure, more recent data show that dapagliflozin at a dose of 10 mg daily, was able to reduce the combined risk of worsening heart failure and cardiovascular death in patients with either a mildly reduced or preserved ejection fraction.
Dapagliflozin use across heart failure ejection fractions
In a patient-level pooled analysis of the only two trials which tested dapagliflozin in heart failure with ejection fractions either ≤40% or >40%, there was no evidence that the effect of the drug varied by ejection fraction. In fact, the combined analysis revealed how dapagliflozin reduced both the risk of cardiovascular death and hospitalisations for heart failure.